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3825 : Disrupting p-STAT3-mediated VEGF-A paracrine and autocrine feed-forward loops by targeting SHP-1 suppresses triple negative breast cancer cell metastasis

Researchers

Presenter

  • Jung-Chen Su

Principal Investigators

  • Hao-Chieh Chiu

  • Chun-Yu Liu

  • Kuen-Feng Chen

  • Chung-Wai Shiau

Medical Centers

  • Department of Clinical Laboratory Sciences and Medical Biotechnology, National Taiwan University, Taipei, Taiwan, Taipei, Taiwan

  • Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan

  • National Center of Excellence for Clinical Trial and Research, National Taiwan University Hospital, Taipei, Taiwan, Taipei, Taiwan

  • National Yang-Ming University, Taipei, Taiwan

Locations

  • Taiwan

Companies

  • N/A

Study Components

Therapeutic Area

  • Oncology (ONC)

Disease

  • Triple-negative breast cancer

  • Gastrointestinal stromal tumor

  • Colorectal Cancer

  • Breast cancer

  • Solid malignancies

Biomarkers

  • Platelet-derived growth factor receptor

  • Kinase Insert Domain Receptor

  • Src homology region 2 domain-containing phosphatase-1

  • Vascular endothelial growth factor A

Drug/Treatment

  • Regorafenib

  • L-Tyrosine

Outcome

  • N/A

Study Design

  • N/A

Phase

  • NA

Study Id's

  • N/A

Sponsors

  • N/A

Result

  • N/A

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