// App-Quantinova.ai

3725 : B-Raf inhibition-induced paradoxical activation of MEK/ERK signaling enhances DR5 expression and DR5 activation-induced apoptosis in Ras-mutant cancer cells

Researchers

Presenter

  • You-Take Oh

Principal Investigators

  • Jiusheng Deng

  • Ping Yue

  • Shi-Yong Sun

Medical Centers

  • Emory University, Winship Cancer Institute, Atlanta, GA

Locations

  • United States

Companies

  • N/A

Study Components

Therapeutic Area

  • Oncology (ONC)

Disease

  • Thyroid Cancer

  • Melanoma

  • Solid malignancies

Biomarkers

  • Raf-1 proto-oncogene, serine/threonine kinase

  • DNA Damage Inducible Transcript 3

Drug/Treatment

  • Vemurafenib

Outcome

  • N/A

Study Design

  • N/A

Phase

  • NA

Study Id's

  • N/A

Sponsors

  • N/A

Result

  • N/A

Copyright © 2026. QuantiNova All rights reserved