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3719 : TAK-243, a small molecule inhibitor of the ubiquitin activating enzyme (UAE), disrupts DNA damage repair and sensitizes tumor cells and xenografts to ionizing radiation

Researchers

Presenter

  • Michael A. Milhollen

Principal Investigators

  • Judy Qiuju Shi

  • Tary Traore

  • Jessica Huck

  • Darshan Sappal

  • Kenichi Iwai

  • Akihiro Ohashi

  • Claudia Rabino

  • Jennifer A. Duffy

  • Eric Lightcap

  • Yuko Ishii

  • Jeffrey Ciavarri

  • Neil Bence

  • Allison J. Berger

  • Marc L. Hyer

Medical Centers

  • Takeda Pharmaceutical Company Limited, Cambridge, MA

  • Takeda Pharmaceutical Company Limited, Fujisawa, Japan

Locations

  • United States

  • Japan

Companies

  • Takeda Pharmaceutica

Study Components

Therapeutic Area

  • Oncology (ONC)

Disease

  • Solid malignancies

Biomarkers

  • Breast cancer type 1 susceptibility protein

  • Tumor suppressor p53-binding protein 1

Drug/Treatment

  • MLN7243

Outcome

  • N/A

Study Design

  • N/A

Phase

  • I

Study Id's

  • N/A

Sponsors

  • N/A

Result

  • N/A

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