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3309 : Novel small molecule ONC201 induces cell death and targets chemotherapy-resistant cancer stem-like cells in triple negative breast cancer

Researchers

Presenter

  • Marie D. Baumeister

Principal Investigators

  • Jessica Wagner

  • Varun V. Prabhu

  • Christina LB Kline

  • Bora Lim

  • Josh E. Allen

  • David T. Dicker

  • Wafik S. El-Deiry

Medical Centers

  • Temple University School of Medicine, Philadelphia, PA

  • Drexel University, Philadelphia, PA

  • Penn State Cancer Institute, Hershey, PA

  • Fox Chase Cancer Center, Philadelphia, PA

  • The University of Texas MD Anderson Cancer Canter, Houston, TX

  • Oncoceutics, Philadelphia, PA

Locations

  • United States

Companies

  • N/A

Study Components

Therapeutic Area

  • Oncology (ONC)

Disease

  • Triple-negative breast cancer

  • Solid malignancies

  • Advanced refractory tumors

  • Breast cancer

Biomarkers

  • DNA Damage Inducible Transcript 3

  • Extracellular signal-regulated kinase

  • TNF superfamily member 10

Drug/Treatment

  • Paclitaxel

  • Methadone hydrochloride

  • TIC 10

Outcome

  • N/A

Study Design

  • Pharmacokinetics

  • First-In-Human

Phase

  • NA

Study Id's

  • NCT02324621

  • NCT02420795

  • NCT02392572

  • NCT02609230

  • NCT02525692

  • NCT02038699

Sponsors

  • N/A

Result

  • N/A

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