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3091 : Development and optimization of a fluorescence polarization-based assay for the discovery of inhibitors of the RBBP4/7-Histone H3 interaction

Researchers

Presenter

  • Rebecca Reed

Principal Investigators

  • Miao-Chia Lo

  • Chang-Ching Lin

  • Duxin Sun

Medical Centers

  • University of Michigan, Ann Arbor, MI

Locations

  • United States

Companies

  • N/A

Study Components

Therapeutic Area

  • Oncology (ONC)

Disease

  • Hematological malignancies

  • Solid malignancies

Biomarkers

  • Polycomb repressive complex 2

  • RB Binding Protein 4, Chromatin Remodeling Factor

  • Embryonic ectoderm development

  • Enhancer of zeste homolog 2

  • Trimethylation of lysine 27 on histone H3

Drug/Treatment

  • EZH2

Outcome

  • N/A

Study Design

  • N/A

Phase

  • NA

Study Id's

  • N/A

Sponsors

  • N/A

Result

  • N/A

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