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2896 : 4E-BP1 hyper-phosphorylation senses microtubule damage and plays a critical role in taxane antitumor activity

Researchers

Presenter

  • Prashant Khade

Principal Investigators

  • Paraskevi Giannakakou

Medical Centers

  • Weill Cornell Medical College of Cornell University, New York, NY

Locations

  • United States

Companies

  • N/A

Study Components

Therapeutic Area

  • Oncology (ONC)

Disease

  • Solid malignancies

Biomarkers

  • Phosphorylated 4E-binding protein 1

  • Cyclin dependent kinase 1

  • Cyclin dependent kinase 2

  • Cyclin dependent kinase 5

  • Hypoxia-inducible factor-1

  • Serine/threonine-protein kinase mTOR

Drug/Treatment

  • Seliciclib

  • taxane

  • Paclitaxel

Outcome

  • N/A

Study Design

  • N/A

Phase

  • NA

Study Id's

  • N/A

Sponsors

  • N/A

Result

  • N/A

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