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2441 : CDK12/13 inhibition cooperates with the Ewing sarcoma oncoprotein EWS/FLI to attenuate homologous recombination repair in Ewing sarcoma cells

Researchers

Presenter

  • Amanda Balboni

Principal Investigators

  • Bjorn Stolte

  • Peter Kalev

  • Nicholas Kwiatkowski

  • Tinghu Zhang

  • Brian Abraham

  • Gabriela Alexe

  • Dipanjan Chowdhury

  • Richard A. Young

  • Nathanael S. Gray

  • Kimberly Stegmaier

Medical Centers

  • Dana-Farber Cancer Institute, Boston, MA

  • Whitehead Institute for Biomedical Research and MIT, Cambridge, MA

Locations

  • United States

Companies

  • N/A

Study Components

Therapeutic Area

  • Oncology (ONC)

Disease

  • Ewing's sarcoma

  • Solid malignancies

  • Sarcoma

Biomarkers

  • Cyclin dependent kinase 7

  • EWS RNA Binding Protein 1

Drug/Treatment

  • Olaparib

  • THZ1

Outcome

  • N/A

Study Design

  • N/A

Phase

  • NA

Study Id's

  • N/A

Sponsors

  • N/A

Result

  • N/A

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