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2438 : Genome-wide screen reveals a role for glucocorticoids in B cell development that can be exploited to improve treatment of B cell acute lymphoblastic leukemia

Researchers

Presenter

  • Miles Pufall

Principal Investigators

  • Karina Kruth

  • Sarah K. Tasian

Medical Centers

  • University of Iowa, Iowa City, IA

  • Childrens Hospital of Philadelphia, Philadelphia, PA

Locations

  • United States

Companies

  • N/A

Study Components

Therapeutic Area

  • Oncology (ONC)

Disease

  • Acute lymphoblastic leukemia

  • Mismatch repair deficiency

  • Solid malignancies

  • B-cell acute lymphoblastic leukemia

Biomarkers

  • B-cell lymphoma 2

  • B-cell lymphoma 6

  • BCL2 like 11

  • Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform

  • Integrin alpha-4

  • Glucocorticoid sensitivity

  • Thioredoxin-interacting protein

Drug/Treatment

  • Glucocorticoid

  • Dexamethasone

  • Dekpak 13 Day Taperpak

Outcome

  • N/A

Study Design

  • N/A

Phase

  • NA

Study Id's

  • N/A

Sponsors

  • N/A

Result

  • N/A

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