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2433 : Loss of chd5-mediated gene repression synergizes with MYCN to accelerate neuroblastoma tumorigenesis in zebrafish

Researchers

Presenter

  • Mark W. Zimmerman

Principal Investigators

  • Shuning He

  • Jimann Shin

  • Shizhen Zhu

  • Feng Guo

  • Marc Mansour

  • Deepak Reyon

  • J Keith Joung

  • Jinhua Quan

  • Timur Yusufzai

  • A Thomas Look

Medical Centers

  • Dana-Farber Cancer Institute, Boston, MA

  • Massachusetts General Hospital, Boston, MA

Locations

  • United States

Companies

  • N/A

Study Components

Therapeutic Area

  • Oncology (ONC)

Disease

  • Neuroblastoma

  • Solid malignancies

Biomarkers

  • MYCN proto-oncogene, bHLH transcription factor

  • Phospho-ERK

  • Proliferating cell nuclear antigen

  • RB Binding Protein 4, Chromatin Remodeling Factor

  • Trimethylation of lysine 27 on histone H3

Drug/Treatment

  • N/A

Outcome

  • N/A

Study Design

  • N/A

Phase

  • NA

Study Id's

  • N/A

Sponsors

  • N/A

Result

  • N/A

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