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1255 : Loss of the ubiquitin protease USP18 represses KRAS mutant lung cancer tumorigenicity in mice by destabilizing KRAS protein

Researchers

Presenter

  • Lisa Maria Mustachio

Principal Investigators

  • Yun Lu

  • Laura J. Tafe

  • Angeline S. Andrew

  • Vincent Memoli

  • Jaime Rodriguez-Canales

  • Pamela A. Villalobos

  • Ignacio Wistuba

  • Jun Yu

  • Jack J. Lee

  • Fadzai Chinyengetere

  • David J. Sekula

  • Xi Liu

  • Sarah J. Freemantle

  • Ethan Dmitrovsky

Medical Centers

  • Geisel School of Medcn At Dartmouth, Lebanon, NH

  • Dartmouth Hitchcock Medical Center, Lebanon, NH

  • The University of Texas MD Anderson Cancer Canter, Houston, TX

Locations

  • United States

Companies

  • N/A

Study Components

Therapeutic Area

  • Oncology (ONC)

Disease

  • Squamous cell carcinoma

  • Lung Cancer

  • Solid malignancies

Biomarkers

  • KRAS proto-oncogene, GTPase

Drug/Treatment

  • N/A

Outcome

  • N/A

Study Design

  • N/A

Phase

  • NA

Study Id's

  • N/A

Sponsors

  • N/A

Result

  • N/A

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