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1137 : Mutation and function of PIK3CA and HRAS in human oral squamous cell carcinoma cells

Researchers

Presenter

  • Hitoshi Akiyama

Principal Investigators

  • Koichi Nakashiro

  • Norihiko Tokuzen

  • Hiroshi Tanaka

  • Satoshi Hino

  • Hiroyuki Hamakawa

Medical Centers

  • Osaka University Graduate School of Medicine, Suita, Japan

Locations

  • Japan

Companies

  • N/A

Study Components

Therapeutic Area

  • Oncology (ONC)

  • Dental and Oral Health

Disease

  • Squamous cell carcinoma of the head and neck

  • Oral Squamous Cell Carcinoma

  • Solid malignancies

Biomarkers

  • AKT Serine

  • Dual specificity mitogen-activated protein kinase kinase 1

  • Neurogenic locus notch homolog protein 1

  • beta-catenin

  • B-Raf proto-oncogene, serine/threonine kinase

  • Phosphatase and tensin homolog

  • Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform

  • Protein Tyrosine Phosphatase, Non-Receptor Type 11

  • Fibroblast growth factor receptor 3

  • HRas Proto-Oncogene, GTPase

  • KIT Proto-Oncogene, Receptor Tyrosine Kinase

  • Serine/threonine-protein kinase mTOR

  • Tumor protein p53

Drug/Treatment

  • Trametinib

  • BEZ-235

  • TP53

Outcome

  • N/A

Study Design

  • N/A

Phase

  • NA

Study Id's

  • N/A

Sponsors

  • N/A

Result

  • N/A

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