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874 : Circadian/melatonin disruption by dim light at night drives paclitaxel resistance in breast cancer via activation of stat3

Researchers

Presenter

  • Steven M. Hill

Principal Investigators

  • Shulin Xiang

  • Robert T. Dauchy

  • Lulu mao

  • Lin Yuan

  • Adam Hauch

  • Victoria P. Belancio

  • Melissa A. Wren-Dail

  • David Pointer

  • Peter W. Lundberg

  • Whitney M. Summers

  • David E. Blask

Medical Centers

  • Tulane University School of Medicine, New Orleans, LA

Locations

  • United States

Companies

  • N/A

Study Components

Therapeutic Area

  • Oncology (ONC)

Disease

  • Breast cancer

  • Solid malignancies

Biomarkers

  • Mitogen-activated protein kinase 3

  • CREB-binding protein

  • Cyclic adenosine monophosphate

  • erb-b2 receptor tyrosine kinase 2

  • Extracellular signal-regulated kinase

  • Ribosomal Protein S6 Kinase A3

  • Signal transducer and activator of transcription 3

Drug/Treatment

  • Doxorubicin

  • Paclitaxel

  • Tamoxifen

  • Melatonin

Outcome

  • N/A

Study Design

  • N/A

Phase

  • NA

Study Id's

  • N/A

Sponsors

  • N/A

Result

  • N/A

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