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331 : Beta-catenin nuclear translocation in colorectal cancer cells is suppressed by PDE10A inhibition, cGMP elevation, and activation of PKG

Researchers

Presenter

  • Kevin J. Lee

Principal Investigators

  • Ashley S. Lindsey

  • Luciana Madeira da Silva

  • Alisa Trinh

  • Bernard Gary

  • Joel Andrews

  • Veronica Ramirez-Alcantara

  • Adam B. Keeton

  • Wen-Chi Chang

  • Margie Clapper

  • Gary A. Piazza

Medical Centers

  • University of South Alabama, Mitchell Cancer Institute, Mobile, AL

  • Fox Chase Cancer Center, Philadelphia, PA

Locations

  • United States

Companies

  • N/A

Study Components

Therapeutic Area

  • Oncology (ONC)

Disease

  • Huntington's disease

  • Colorectal Cancer

  • Schizophrenia

  • Solid malignancies

Biomarkers

  • beta-catenin

  • Cyclic adenosine monophosphate

  • Cyclic AMP-dependent protein kinase

Drug/Treatment

  • MP-10

Outcome

  • N/A

Study Design

  • N/A

Phase

  • NA

Study Id's

  • N/A

Sponsors

  • N/A

Result

  • N/A

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