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TPS9105 : Avelumab (MSB0010718C; anti-PD-L1) vs platinum-based doublet as first-line treatment for metastatic or recurrent PD-L1-positive non-small-cell lung cancer: The phase 3 JAVELIN Lung 100 trial.

Researchers

Presenter

  • Martin Reck

Principal Investigators

  • Hyatt P. DeGreen

  • Andrea L. Rose

  • Nick Pavlakis

  • Sofie Maria Derjcke

  • Jasna Radic

  • Nina Jeppesen

  • Michael Thomas

  • Gyorgy Losonczy

  • Ewa Kalinka-Warzocha

  • Lydia Mary Dreosti

  • Mustafa Ozguroglu

  • Pieter E. Postmus

  • Christoph Helwig

  • Vikram Chand

  • Jean-Marie Cuillerot

  • Virginie Westeel

Medical Centers

  • Lung Clinic Grosshansdorf, Airway Research Center North (ARCN), member of the German Center for Lung Research (DZL), Grosshansdorf, Germany

  • Lancaster Cancer Center, Lancaster, PA

  • Northwest Medical Specialties, PLLC, Puyallup, WA

  • Department of Medical Oncology, Royal North Shore Hospital, The University of Sydney, Sydney, Australia

  • AZ Groeninge, Kortrijk, Belgium

  • Clinical Hospital Center Sestre, Sestre Milosrdnice, Zagreb, Croatia

  • Department of Oncology, Roskilde Hospital, Roskilde, Denmark

  • University Clinic Heidelberg, Heidelberg, Germany

  • Department of Pulmonology, Semmelweis University, Budapest, Hungary

  • Regional Oncology Center, Gdansk, Poland

  • University of Pretoria, Pretoria, South Africa

  • Istanbul University, Istanbul, Turkey

  • University of Liverpool, Clatterbridge Cancer Centre NHS Foundation Trust, Wirral, United Kingdom

  • Merck KGaA, Darmstadt, Germany

  • EMD Serono, Inc, Billerica, MA

  • EMD Serono, Inc, Billerica, MA

  • Centre Hospitalier Unversitaire Besancon, Besancon, France

Locations

  • South Africa

  • Poland

  • Germany

  • Turkey

  • United Kingdom

  • Croatia

  • Australia

  • United States

  • France

  • Denmark

  • Belgium

  • Hungary

Companies

  • Northwest Medical Sp

Study Components

Therapeutic Area

  • Oncology (ONC)

Disease

  • Non Small Cell Lung cancer

Biomarkers

  • Anaplastic lymphoma Kinase

  • Epidermal growth factor receptor

Drug/Treatment

  • Carboplatin

  • Gemcitabine

  • Avelumab

  • Paclitaxel

  • Pemetrexed

  • Cisplatin

Outcome

  • N/A

Study Design

  • Randomized

  • Superiority

  • Multicenteric

Phase

  • III

Study Id's

  • NCT02576574

Sponsors

  • N/A

Result

  • N/A

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