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4017 : Phase III Randomized Study of Second Line ADI-Peg 20 (A) Plus Best Supportive Care Versus Placebo (P) Plus Best Supportive Care in Patients with Advanced Hepatocellular Carcinoma

Researchers

Presenter

  • Ghassan K. Abou-Alfa

Principal Investigators

  • Baek-Yeol Ryoo

  • Sheng-Nan Lu

  • Chia-Jui Yen

  • Yin-Hsun Feng

  • Ho Yeong Lim

  • Francesco Izzo

  • Massimo Colombo

  • Debashis Sarker

  • Luigi Bolondi

  • Gina M. Vaccaro

  • William Proctor Harris

  • Zhendong Chen

  • Richard Hubner

  • Tim Meyer

  • John S. Bomalaski

  • Chen Chun Lin

  • Yee Chao

  • Li-Tzong Chen

Medical Centers

  • Memorial Sloan Kettering Cancer Center, Port Washington, NY

  • The Chinese People's Liberation Army 81 Hospital, Nanjing, China

  • Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan

  • National Cheng Kung University Hospital, Tainan City, Taiwan

  • Chi Mei Medical Centre Yongkang, Tainan City, Taiwan

  • National Cancer Institute of Naples G.Pascale Foudation, Napoli, Italy

  • Maggiore Hospital, Milan, Italy

  • Department of Oncology, King's College Hospital, London, United Kingdom

  • Department of Medical and Surgical Sciences, University of Bologna and Center for Applied Biomedical Research (CRBA), S.Orsola-Malpighi Hospital, Bologna, Italy

  • Oregon Health and Science University, Portland, OR

  • University of Washington School of Medicine, Seattle, WA

  • 2th Hospital of Anhui Medical Unive, Hefei, China

  • The Christie NHS Foundation TRUST, Manchester, United Kingdom

  • UCL Cancer Institute, University College London,, London, United Kingdom

  • Polaris Pharmaceuticals Inc, San Diego, CA

  • Chang Gung Medical Foundatio LK, Taoyuan, Taiwan

  • Taipei Veterans General Hospital, Taipei City, Taiwan

  • National Health Research Institutes (NHRI) - National Institute of Cancer Research, Taipei, Taiwan

Locations

  • China

  • Taiwan

  • Italy

  • United Kingdom

  • United States

Companies

  • N/A

Study Components

Therapeutic Area

  • Oncology (ONC)

Disease

  • Liver cancer

Biomarkers

  • N/A

Drug/Treatment

  • Pegargiminase

  • Sorafenib

Outcome

  • Positive


Study Design

  • Randomized

  • Placebo Control

Phase

  • III

Study Id's

  • NCT01287585

Sponsors

  • N/A

Result

  • Final