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3584 : A systems model of BCL-2 dependent apoptosis to predict stage II CRC patients benefiting from adjuvant chemotherapy and as a prognostic tool for stage III CRC patients with increased risk of recurrence.

Researchers

Presenter

  • Jochen Prehn

Principal Investigators

  • Manuela Salvucci

  • Mattia Cremona

  • Naser Monsefi

  • Sarah Curry

  • Clare Morgan

  • Alexa Resler

  • Robert O'Byrne

  • Orna Bacon

  • Lorna Flanagan

  • Richard H. Wilson

  • Patrick G Johnston

  • Manuel Salto-Tellez

  • Sophie Camilleri-Broet

  • Deborah A McNamara

  • Bryan T Hennessy

  • Elaine Kay

  • Pierre Laurent-Puig

  • Sandra Van Schaeybroeck

Medical Centers

  • Royal College of Surgeons in Ireland, Centre for Systems Medicine, Department of Pathology, Beaumont Hospital, Dublin, Ireland

  • Royal College of Surgeons in Ireland, Centre for Systems Medicine, Department of Pathology, Beaumont Hospital, Dublin, Ireland

  • Royal College of Surgeons in Ireland, Centre for Systems Medicine, Dublin, Ireland

  • Royal College of Surgeons in Ireland, Centre for Systems Medicine, Department of Pathology, Beaumont Hospital, Dublin, Ireland

  • Centre for Cancer Research and Cell Biology, Queen's University Belfast, Belfast, United Kingdom

  • Queen's Univeristy Belfast, Centre for Cancer and Cell Biology, Belfast, United Kingdom

  • Universite Paris Descartes, Paris, France

  • Beaumont Hospital, Department of Surgery, Dublin, Ireland

  • Beaumont Hospital, Department of Medical Oncology, Dublin, Ireland

  • Department of Histopathology, Beaumont Hospital, Dublin 9, Dublin, Ireland

  • Paris Descartes University, Paris, France

Locations

  • France

  • Ireland

  • United Kingdom

Companies

  • N/A

Study Components

Therapeutic Area

  • Pulmonary/Respiratory Diseases

Disease

  • Chronic obstructive pulmonary disease

Biomarkers

  • Myeloid Cell Leukemia 1

  • B-cell lymphoma 2

  • BCL2 associated X, apoptosis regulator

  • Nucleoside diphosphate kinase A

Drug/Treatment

  • Adrucil injection

Outcome

  • N/A

Study Design

  • Randomized

  • Cohort

Phase

  • NA

Study Id's

  • N/A

Sponsors

  • N/A

Result

  • Final

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